SCOPe 2.08: Domain d4rmga1: 4rmg A:56-356

Lineage for d4rmga1 (4rmg A:56-356)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (8 proteins)
   silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

6. Protein Sirt2 histone deacetylase [63987] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63988] (23 PDB entries)

8. Domain d4rmga1: 4rmg A:56-356 [269355]
   Other proteins in same PDB: d4rmga2
   automated match to d1j8fc_
   complexed with 3te, nad, zn

Details for d4rmga1

PDB Entry: 4rmg, 1.88 Å

PDB Description: Human Sirt2 in complex with SirReal2 and NAD+

PDB Compounds: (A:) nad-dependent protein deacetylase sirtuin-2

SCOPe Domain Sequences for d4rmga1:

Sequence, based on SEQRES records:

>d4rmga1 c.31.1.5 (A:56-356) Sirt2 histone deacetylase {Human (Homo sapiens) [TaxId: 9606]}
erlldeltlegvarymqsercrrviclvgagistsagipdfrspstglydnlekyhlpyp
eaifeisyfkkhpepffalakelypgqfkptichyfmrllkdkglllrcytqnidtleri
agleqedlveahgtfytshcvsascrheyplswmkekifsevtpkcedcqslvkpdivff
geslparffscmqsdflkvdlllvmgtslqvqpfasliskaplstprllinkekagqsdp
flgmimglgggmdfdskkayrdvawlgecdqgclalaellgwkkeledlvrrehasidaq
s

Sequence, based on observed residues (ATOM records):

>d4rmga1 c.31.1.5 (A:56-356) Sirt2 histone deacetylase {Human (Homo sapiens) [TaxId: 9606]}
erlldeltlegvarymqsercrrviclvgagistsagipdfrsplydnlekyhlpypeai
feisyfkkhpepffalakelypgqfkptichyfmrllkdkglllrcytqnidtleriagl
eqedlveahgtfytshcvsascrheyplswmkekifsevtpkcedcqslvkpdivffges
lparffscmqsdflkvdlllvmgtslqvqpfasliskaplstprllinkekagqsdgmim
glgggmdfdskkayrdvawlgecdqgclalaellgwkkeledlvrrehasidaqs

Timeline for d4rmga1:

• d4rmga1 first appeared in SCOPe 2.05, called d4rmga_
  
• d4rmga1 appears in SCOPe 2.07