SCOP 1.73: Domain d1fknb_: 1fkn B:

Lineage for d1fknb_ (1fkn B:)

1. Root: SCOP 1.73

2. Class b: All beta proteins [48724] (165 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (2 families)

5. Family b.50.1.2: Pepsin-like [50646] (10 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (30 PDB entries)

8. Domain d1fknb_: 1fkn B: [26880]
   complexed with alq, lol

Details for d1fknb_

PDB Entry: 1fkn, 1.9 Å

PDB Description: Structure of Beta-Secretase Complexed with Inhibitor

PDB Compounds: (B:) memapsin 2

SCOP Domain Sequences for d1fknb_:

Sequence; same for both SEQRES and ATOM records:

>d1fknb_ b.50.1.2 (B:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmii
ggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrl
pkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsf
ritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfav
sachvhdefrtaavegpfvtldmedcgyn

Timeline for d1fknb_:

• d1fknb_ first appeared (with stable ids) in SCOP 1.55
  
• d1fknb_ appears in SCOP 1.71
  
• d1fknb_ appears in SCOP 1.75
  
• d1fknb_ appears in the current release, SCOPe 2.08