SCOPe 2.08: Domain d4rfya_: 4rfy A:

Lineage for d4rfya_ (4rfy A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d4rfya_: 4rfy A: [268776]
   automated match to d3pj2a_
   complexed with 3ou, dms

Details for d4rfya_

PDB Entry: 4rfy, 1.7 Å

PDB Description: crystal structure of btk kinase domain complexed with 6- (dimethylamino)-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(morpholine-4- carbonyl)-2-pyridyl]amino]-6-oxo-3-pyridyl]phenyl]-3,4- dihydroisoquinolin-1-one

PDB Compounds: (A:) Tyrosine-protein kinase BTK

SCOPe Domain Sequences for d4rfya_:

Sequence; same for both SEQRES and ATOM records:

>d4rfya_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmnlshe
klvqlygvctkqrpifiiteymangcllnylrearhafqtqqllemckdvceameylesk
qflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlmyskfs
sksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasaavytimyscwh
ekaderptfkillsnildvmdee

Timeline for d4rfya_:

• d4rfya_ first appeared in SCOPe 2.05
  
• d4rfya_ appears in SCOPe 2.07