SCOP 1.75: Domain d2rena_: 2ren A:

Lineage for d2rena_ (2ren A:)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (3 families)

5. Family b.50.1.2: Pepsin-like [50646] (10 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein Chymosin (synonym: renin) [50667] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50669] (6 PDB entries)

8. Domain d2rena_: 2ren A: [26874]
   complexed with nag

Details for d2rena_

PDB Entry: 2ren, 2.5 Å

PDB Description: structure of recombinant human renin, a target for cardiovascular- active drugs, at 2.5 angstroms resolution

PDB Compounds: (A:) renin

SCOP Domain Sequences for d2rena_:

Sequence, based on SEQRES records:

>d2rena_ b.50.1.2 (A:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
gnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhkl
fdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlae
fdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlggsdp
qhyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklm
ealgakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaiham
dippptgptwalgatfirkfytefdrrnnrigfalar

Sequence, based on observed residues (ATOM records):

>d2rena_ b.50.1.2 (A:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
gnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcstacvyhklfda
sdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlaefdg
vvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdslggqivlggsdpqhyegnfh
yinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmealgakkr
lfdyvvkcnegptlpdisfhlggkeytltsadyvfctlaihamdippptgptwalgatfi
rkfytefdrrnnrigfalar

Timeline for d2rena_:

• d2rena_ first appeared (with stable ids) in SCOP 1.55, called d2ren__
  
• d2rena_ appears in SCOP 1.73
  
• d2rena_ appears in SCOPe 2.01
  
• d2rena_ appears in the current release, SCOPe 2.08