SCOPe 2.08: Domain d1rnea_: 1rne A:

Lineage for d1rnea_ (1rne A:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein Chymosin (synonym: renin) [50667] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50669] (77 PDB entries)

8. Domain d1rnea_: 1rne A: [26871]
   complexed with c60, nag

Details for d1rnea_

PDB Entry: 1rne, 2.4 Å

PDB Description: the crystal structure of recombinant glycosylated human renin alone and in complex with a transition state analog inhibitor

PDB Compounds: (A:) renin

SCOPe Domain Sequences for d1rnea_:

Sequence, based on SEQRES records:

>d1rnea_ b.50.1.2 (A:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
nttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhklf
dasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlaef
dgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlggsdpq
hyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklme
algakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamd
ippptgptwalgatfirkfytefdrrnnrigfalar

Sequence, based on observed residues (ATOM records):

>d1rnea_ b.50.1.2 (A:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
nttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhklf
dasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlaef
dgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdlggqivlggsdpqhyegnf
hyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmealgakk
rlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdippptg
ptwalgatfirkfytefdrrnnrigfalar

Timeline for d1rnea_:

• d1rnea_ first appeared (with stable ids) in SCOP 1.55, called d1rne__
  
• d1rnea_ appears in SCOPe 2.07