SCOP 1.71: Domain d1hrnb_: 1hrn B:

Lineage for d1hrnb_ (1hrn B:)

1. Root: SCOP 1.71

2. Class b: All beta proteins [48724] (149 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (2 families)

5. Family b.50.1.2: Pepsin-like [50646] (10 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein Chymosin (synonym: renin) [50667] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50669] (9 PDB entries)

8. Domain d1hrnb_: 1hrn B: [26870]
   complexed with cha, cpp, ip3, nag, ppp

Details for d1hrnb_

PDB Entry: 1hrn, 1.8 Å

PDB Description: high resolution crystal structures of recombinant human renin in complex with polyhydroxymonoamide inhibitors

SCOP Domain Sequences for d1hrnb_:

Sequence, based on SEQRES records:

>d1hrnb_ b.50.1.2 (B:) Chymosin (synonym: renin) {Human (Homo sapiens)}
gnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhkl
fdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlae
fdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlggsdp
qhyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklm
ealgakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaiham
dippptgptwalgatfirkfytefdrrnnrigfalar

Sequence, based on observed residues (ATOM records):

>d1hrnb_ b.50.1.2 (B:) Chymosin (synonym: renin) {Human (Homo sapiens)}
gnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhkl
fdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlae
fdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdseslggqivlggsdpqhy
egnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklmeal
gakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdip
pptgptwalgatfirkfytefdrrnnrigfalar

Timeline for d1hrnb_:

• d1hrnb_ first appeared (with stable ids) in SCOP 1.55
  
• d1hrnb_ appears in SCOP 1.69
  
• d1hrnb_ appears in SCOP 1.73
  
• d1hrnb_ appears in the current release, SCOPe 2.08