Lineage for d4qd6a1 (4qd6 A:357-619)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2542316Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2544952Protein Tyrosine-protein kinase Itk/Tsk [111194] (1 species)
    PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase
  7. 2544953Species Human (Homo sapiens) [TaxId:9606] [111195] (33 PDB entries)
    Uniprot Q08881 357-619
  8. 2544994Domain d4qd6a1: 4qd6 A:357-619 [268678]
    Other proteins in same PDB: d4qd6a2, d4qd6b2
    automated match to d4l7sa_
    complexed with 30t

Details for d4qd6a1

PDB Entry: 4qd6 (more details), 2.45 Å

PDB Description: ITK kinase domain in complex with inhibitor compound
PDB Compounds: (A:) Tyrosine-protein kinase ITK/TSK

SCOPe Domain Sequences for d4qd6a1:

Sequence, based on SEQRES records: (download)

>d4qd6a1 d.144.1.7 (A:357-619) Tyrosine-protein kinase Itk/Tsk {Human (Homo sapiens) [TaxId: 9606]}
vidpseltfvqeigsgqfglvhlgywlnkdkvaiktiregamseedfieeaevmmklshp
klvqlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayleea
cvihrdlaarnclvgenqvikvsdfgmtrfvlddqetsstgtkfpvkwaspevfsfsrys
sksdvwsfgvlmwevfsegkipyenrsnsevvedistgfrlykprlasthvyqimnhcwk
erpedrpafsrllrqlaeiaesg

Sequence, based on observed residues (ATOM records): (download)

>d4qd6a1 d.144.1.7 (A:357-619) Tyrosine-protein kinase Itk/Tsk {Human (Homo sapiens) [TaxId: 9606]}
vidpseltfvqeigsgqfglvhlgywlnkdkvaiktiseedfieeaevmmklshpklvql
ygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayleeacvihr
dlaarnclvgenqvikvsdfgmtpvkwaspevfsfsryssksdvwsfgvlmwevfsegki
pyenrsnsevvedistgfrlykprlasthvyqimnhcwkerpedrpafsrllrqlaeiae
sg

SCOPe Domain Coordinates for d4qd6a1:

Click to download the PDB-style file with coordinates for d4qd6a1.
(The format of our PDB-style files is described here.)

Timeline for d4qd6a1:

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Domains from same chain:
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d4qd6a2