SCOPe 2.07: Domain d1avf.2: 1avf Q:,J:

Lineage for d1avf.2 (1avf Q:,J:)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein Pepsin(ogen) [50658] (4 species)

7. Species Human (Homo sapiens), progastricsin (pepsinogen C) [TaxId:9606] [50661] (2 PDB entries)

8. Domain d1avf.2: 1avf Q:,J: [26854]
   activation intermediate 2
   complexed with na

Details for d1avf.2

PDB Entry: 1avf, 2.36 Å

PDB Description: activation intermediate 2 of human gastricsin from human stomach

PDB Compounds: (J:) gastricsin, (Q:) gastricsin

SCOPe Domain Sequences for d1avf.2:

Sequence, based on SEQRES records:

>g1avf.2 b.50.1.2 (Q:,J:) Pepsin(ogen) {Human (Homo sapiens), progastricsin (pepsinogen C) [TaxId: 9606]}
avvkvplkkfksiretmkekglXvtyepmaymdaayfgeisigtppqnflvlfdtgssnl
wvpsvycqsqactshsrfnpsesstystngqtfslqygsgsltgffgydtltvqsiqvpn
qefglsenepgtnfvyaqfdgimglaypalsvdeattamqgmvqegaltspvfsvylsnq
qgssggavvfggvdsslytgqiywapvtqelywqigieefliggqasgwcsegcqaivdt
gtslltvpqqymsallqatgaqedeygqflvncnsiqnlpsltfiingvefplppssyil
snngyctvgveptylssqngqplwilgdvflrsyysvydlgnnrvgfataa

Sequence, based on observed residues (ATOM records):

>g1avf.2 b.50.1.2 (Q:,J:) Pepsin(ogen) {Human (Homo sapiens), progastricsin (pepsinogen C) [TaxId: 9606]}
avvkvplkkfksiretmkekglXvtyepmaymdaayfgeisigtppqnflvlfdtgssnl
wvpsvycqsqactshsrfnpsesstystngqtfslqygsgsltgffgydtltvqsiqvpn
qefglsenepgtnfvyaqfdgimglaypalsvdeattamqgmvqegaltspvfsvylsng
gavvfggvdsslytgqiywapvtqelywqigieefliggqasgwcsegcqaivdtgtsll
tvpqqymsallqatgaqedeygqflvncnsiqnlpsltfiingvefplppssyilsnngy
ctvgveptylssqngqplwilgdvflrsyysvydlgnnrvgfataa

Timeline for d1avf.2:

• d1avf.2 first appeared (with stable ids) in SCOP 1.55
  
• d1avf.2 appears in SCOPe 2.06
  
• d1avf.2 appears in the current release, SCOPe 2.08