SCOPe 2.08: Domain d4ogua_: 4ogu A:

Lineage for d4ogua_ (4ogu A:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.128: Terpenoid synthases [48575] (1 superfamily)
   multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers

4. Superfamily a.128.1: Terpenoid synthases [48576] (6 families)
   duplication: two metal-binding sites are related by a pseudo dyad that also relates helices C-F to helices G-J

5. Family a.128.1.1: Isoprenyl diphosphate synthases [48577] (4 proteins)

6. Protein automated matches [190489] (5 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187688] (85 PDB entries)

8. Domain d4ogua_: 4ogu A: [268519]
   automated match to d4demf_
   complexed with 210, ipe, mg; mutant

Details for d4ogua_

PDB Entry: 4ogu, 2.1 Å

PDB Description: the effects of lysine 200 and phenylalanine 239 farnesyl pyrophosphate synthase (fpps) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates

PDB Compounds: (A:) farnesyl pyrophosphate synthase

SCOPe Domain Sequences for d4ogua_:

Sequence, based on SEQRES records:

>d4ogua_ a.128.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dvyaqekqdfvqhfsqivrvltedemghpeigdaiarlkevleyntiggkynrgltvvva
frelveprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgld
aindanlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvr
ftekryksivkyktafysfylpiaaamymagidgekehanakkillemgefaqiqddyld
lfgdpsvtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyee
ldlpavflqyeedsyshimalieqyaaplppavflglarkiyk

Sequence, based on observed residues (ATOM records):

>d4ogua_ a.128.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dvyaqekqdfvqhfsqivrvltehpeigdaiarlkevleyntiggkynrgltvvvafrel
veprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgldaind
anlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvrftek
ryksivkyktafysfylpiaaamymagidgekehanakkillemgefaqiqddyldlfgd
psvtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyeeldlp
avflqyeedsyshimalieqyaaplppavflglarkiyk

Timeline for d4ogua_:

• d4ogua_ first appeared in SCOPe 2.05
  
• d4ogua_ appears in SCOPe 2.07