SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d4cmgd_ (4cmg D:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2090218Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2090219Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2094257Family c.2.1.0: automated matches [191313] (1 protein)
    not a true family
  6. 2094258Protein automated matches [190069] (222 species)
    not a true protein
  7. 2096189Species Trypanosoma brucei [TaxId:5702] [226801] (37 PDB entries)
  8. 2096309Domain d4cmgd_: 4cmg D: [268241]
    automated match to d4kwib_
    complexed with act, nap, uhx

Details for d4cmgd_

PDB Entry: 4cmg (more details), 2 Å

PDB Description: Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor
PDB Compounds: (D:) pteridine reductase 1

SCOPe Domain Sequences for d4cmgd_:

Sequence, based on SEQRES records: (download)

>d4cmgd_ c.2.1.0 (D:) automated matches {Trypanosoma brucei [TaxId: 5702]}
eapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcqa
dltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvqgdhednsngktvetqva
eligtnaiapflltmsfaqrqkgtnpnctssnlsivnlcdamvdqpcmafslynmgkhal
vgltqsaalelapygirvngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiadav
iflvsgsaqyitgsiikvdgglslvha

Sequence, based on observed residues (ATOM records): (download)

>d4cmgd_ c.2.1.0 (D:) automated matches {Trypanosoma brucei [TaxId: 5702]}
eapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcqa
dltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvgktvetqvaeligtnaia
pflltmsfaqrqssnlsivnlcdamvdqpcmafslynmgkhalvgltqsaalelapygir
vngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiadaviflvsgsaqyitgsiik
vdgglslvha

SCOPe Domain Coordinates for d4cmgd_:

Click to download the PDB-style file with coordinates for d4cmgd_.
(The format of our PDB-style files is described here.)

Timeline for d4cmgd_: