SCOPe 2.08: Domain d3wwra_: 3wwr A:

Lineage for d3wwra_ (3wwr A:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Vitamin D nuclear receptor [48528] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48529] (30 PDB entries)

8. Domain d3wwra_: 3wwr A: [268106]
   automated match to d3ilza_
   complexed with 3aj

Details for d3wwra_

PDB Entry: 3wwr, 3.18 Å

PDB Description: crystal structure of the human vitamin d receptor ligand binding domain complexed with 1-((((1s,2r,6r,z)-2,6-dihydroxy-4-((e)-2-((1r, 3as,7ar)-1-((r)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1h- inden-4(2h)-ylidene)ethylidene)-3-methylenecyclohexyl)oxy)methyl) cyclopropanecarbonitrile

PDB Compounds: (A:) Vitamin D3 receptor

SCOPe Domain Sequences for d3wwra_:

Sequence, based on SEQRES records:

>d3wwra_ a.123.1.1 (A:) Vitamin D nuclear receptor {Human (Homo sapiens) [TaxId: 9606]}
dslrpklseeqqriiailldahhktydptysdfcqfrppvrvndgggsvtlelsqlsmlp
hladlvsysiqkvigfakmipgfrdltsedqivllkssaievimlrsnesftmddmswtc
gnqdykyrvsdvtkaghslelieplikfqvglkklnlheeehvllmaicivspdrpgvqd
aalieaiqdrlsntlqtyircrhpppgshllyakmiqkladlrslneehskqyrclsfqp
ecsmkltplvlevfg

Sequence, based on observed residues (ATOM records):

>d3wwra_ a.123.1.1 (A:) Vitamin D nuclear receptor {Human (Homo sapiens) [TaxId: 9606]}
dslrpklseeqqriiailldahhktydptysdfcqfrppvrvndggsvtlelsqlsmlph
ladlvsysiqkvigfakmipgfrdltsedqivllkssaievimlrsnesftmddmswtcg
nqdykyrvsdvtkaghslelieplikfqvglkklnlheeehvllmaicivspdrpgvqda
alieaiqdrlsntlqtyircrhpppgshllyakmiqkladlrslneehskqyrclsfqpe
csmkltplvlevfg

Timeline for d3wwra_:

• d3wwra_ first appeared in SCOPe 2.05
  
• d3wwra_ appears in SCOPe 2.07