SCOPe 2.08: Protein: Methyltransferase domain from DNA methyltransferase 1 (DNMT1)

Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest
Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (61 families)
Family c.66.1.26: C5 cytosine-specific DNA methylase, DCM [88786] (5 proteins)
automatically mapped to Pfam PF00145
Protein Methyltransferase domain from DNA methyltransferase 1 (DNMT1) [267659] (2 species)

Human (Homo sapiens) [TaxId:9606] [267738] (1 PDB entry)
- Domain for 3pta:
  - Domain d3ptaa5: 3pta A:1135-1600 [265231]
    Other proteins in same PDB: d3ptaa1, d3ptaa2, d3ptaa3, d3ptaa4
    protein/DNA complex; complexed with sah, zn
Mouse (Mus musculus) [TaxId:10090] [267737] (4 PDB entries)
1. Domains for 3pt6:
  1. Domain d3pt6a5: 3pt6 A:1139-1600 [265218]
    Other proteins in same PDB: d3pt6a1, d3pt6a2, d3pt6a3, d3pt6a4, d3pt6b1, d3pt6b2, d3pt6b3, d3pt6b4
    protein/DNA complex; complexed with sah, zn
  2. Domain d3pt6b5: 3pt6 B:1138-1600 [265223]
    Other proteins in same PDB: d3pt6a1, d3pt6a2, d3pt6a3, d3pt6a4, d3pt6b1, d3pt6b2, d3pt6b3, d3pt6b4
    protein/DNA complex; complexed with sah, zn
2. Domain for 3pt9:
  - Domain d3pt9a3: 3pt9 A:1137-1600 [265226]
    Other proteins in same PDB: d3pt9a1, d3pt9a2, d3pt9a4
    automated match to d3ptaa5
    complexed with sah, zn
3. Domain for 5gut:
  - Domain d5guta3: 5gut A:1139-1599 [338478]
    Other proteins in same PDB: d5guta1, d5guta2
    automated match to d3pt9a3
    complexed with sah, so4, zn; mutant
4. Domain for 5guv:
  - Domain d5guva3: 5guv A:1137-1600 [338580]
    Other proteins in same PDB: d5guva1, d5guva2
    automated match to d3pt9a3
    complexed with zn; mutant

Timeline for Protein Methyltransferase domain from DNA methyltransferase 1 (DNMT1) from c.66.1.26: C5 cytosine-specific DNA methylase, DCM:

Protein Methyltransferase domain from DNA methyltransferase 1 (DNMT1) from c.66.1.26: C5 cytosine-specific DNA methylase, DCM first appeared in SCOPe 2.05
Protein Methyltransferase domain from DNA methyltransferase 1 (DNMT1) from c.66.1.26: C5 cytosine-specific DNA methylase, DCM appears in SCOPe 2.07