SCOPe 2.08: Domain d4uqha1: 4uqh A:32-477

Lineage for d4uqha1 (4uqh A:32-477)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.104: Cytochrome P450 [48263] (1 superfamily)
   multihelical

4. Superfamily a.104.1: Cytochrome P450 [48264] (2 families)

5. Family a.104.1.0: automated matches [191509] (1 protein)
   not a true family

6. Protein automated matches [190847] (99 species)
   not a true protein

7. Species Trypanosoma cruzi [TaxId:5693] [196511] (20 PDB entries)

8. Domain d4uqha1: 4uqh A:32-477 [267470]
   Other proteins in same PDB: d4uqha2
   automated match to d3khma_
   complexed with 25s, hem, so4

Details for d4uqha1

PDB Entry: 4uqh, 2.43 Å

PDB Description: Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-4-(4-(3,4-difluorophenyl)piperazin-1-yl)-2-fluorobenzamide.

PDB Compounds: (A:) Sterol 14-alpha demethylase

SCOPe Domain Sequences for d4uqha1:

Sequence, based on SEQRES records:

>d4uqha1 a.104.1.0 (A:32-477) automated matches {Trypanosoma cruzi [TaxId: 5693]}
ppvypvtvpflghivqfgknplefmqrckrdlksgvftisiggqrvtivgdphehsrffs
prneilsprevytimtpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiqhevr
kfmaenwkedegvinlledcgamiintacqclfgedlrkrlnarhfaqllskmesslipa
avfmpwllrlplpqsarcrearaelqkilgeiivarekeeaskdnntsdllggllkavyr
dgtrmslhevcgmivaamfagqhtstittswsmlhlmhpknkkwldklhkeidefpaqln
ydnvmdempfaercvresirrdppllmvmrmvkaevkvgsyvvpkgdiiacspllshhde
eafpnprlwdperdekvdgafigfgagvhkcigqkfallqvktilatafreydfqllrde
vpdpdyhtmvvgptlnqclvkytrkk

Sequence, based on observed residues (ATOM records):

>d4uqha1 a.104.1.0 (A:32-477) automated matches {Trypanosoma cruzi [TaxId: 5693]}
ppvypvtvpflghivqfgknplefmqrckrdlksgvftisiggqrvtivgdphehsrffs
prneilsprevytimtpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiqhevr
kfmaenwkedegvinlledcgamiintacqclfgedlrkrlnarhfaqllskmesslipa
avfmpwllrlplpqsarcrearaelqkilgeiivareketsdllggllkavyrdgtrmsl
hevcgmivaamfagqhtstittswsmlhlmhpknkkwldklhkeidefpaqlnydnvmde
mpfaercvresirrdppllmvmrmvkaevkvgsyvvpkgdiiacspllshhdeeafpnpr
lwdperdekvdgafigfgagvhkcigqkfallqvktilatafreydfqllrdevpdpdyh
tmvvgptlnqclvkytrkk

Timeline for d4uqha1:

• d4uqha1 first appeared in SCOPe 2.05, called d4uqha_
  
• d4uqha1 appears in SCOPe 2.07