SCOPe 2.08: Domain d4ppab1: 4ppa B:357-619

Lineage for d4ppab1 (4ppa B:357-619)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Tyrosine-protein kinase Itk/Tsk [111194] (1 species)
   PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [111195] (33 PDB entries)
   Uniprot Q08881 357-619

8. Domain d4ppab1: 4ppa B:357-619 [267199]
   Other proteins in same PDB: d4ppaa2, d4ppab2
   automated match to d4l7sa_
   complexed with 2vu

Details for d4ppab1

PDB Entry: 4ppa, 2.67 Å

PDB Description: itk kinase domain with compound 11 (n-[1-(3-cyanobenzyl)-1h-pyrazol-4- yl]-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide)

PDB Compounds: (B:) Tyrosine-protein kinase ITK/TSK

SCOPe Domain Sequences for d4ppab1:

Sequence, based on SEQRES records:

>d4ppab1 d.144.1.7 (B:357-619) Tyrosine-protein kinase Itk/Tsk {Human (Homo sapiens) [TaxId: 9606]}
vidpseltfvqeigsgqfglvhlgywlnkdkvaiktiregamseedfieeaevmmklshp
klvqlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayleea
cvihrdlaarnclvgenqvikvsdfgmtrfvlddqetsstgtkfpvkwaspevfsfsrys
sksdvwsfgvlmwevfsegkipyenrsnsevvedistgfrlykprlasthvyqimnhcwk
erpedrpafsrllrqlaeiaesg

Sequence, based on observed residues (ATOM records):

>d4ppab1 d.144.1.7 (B:357-619) Tyrosine-protein kinase Itk/Tsk {Human (Homo sapiens) [TaxId: 9606]}
vidpseltfvqeigsgqfglvhlgywlnkdkvaiktiedfieeaevmmklshpklvqlyg
vcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayleeacvihrdl
aarnclvgenqvikvsdfgpvkwaspevfsfsryssksdvwsfgvlmwevfsegkipyen
rsnsevvedistgfrlykprlasthvyqimnhcwkerpedrpafsrllrqlaeiaesg

Timeline for d4ppab1:

• d4ppab1 first appeared in SCOPe 2.05, called d4ppab_
  
• d4ppab1 appears in SCOPe 2.07