Lineage for d4ppaa1 (4ppa A:357-619)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2542316Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2544952Protein Tyrosine-protein kinase Itk/Tsk [111194] (1 species)
    PTK group; Tec/Atk subfamily; non-membrane spanning protein tyrosine kinase
  7. 2544953Species Human (Homo sapiens) [TaxId:9606] [111195] (33 PDB entries)
    Uniprot Q08881 357-619
  8. 2545004Domain d4ppaa1: 4ppa A:357-619 [267198]
    Other proteins in same PDB: d4ppaa2, d4ppab2
    automated match to d4l7sa_
    complexed with 2vu

Details for d4ppaa1

PDB Entry: 4ppa (more details), 2.67 Å

PDB Description: itk kinase domain with compound 11 (n-[1-(3-cyanobenzyl)-1h-pyrazol-4- yl]-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide)
PDB Compounds: (A:) Tyrosine-protein kinase ITK/TSK

SCOPe Domain Sequences for d4ppaa1:

Sequence, based on SEQRES records: (download)

>d4ppaa1 d.144.1.7 (A:357-619) Tyrosine-protein kinase Itk/Tsk {Human (Homo sapiens) [TaxId: 9606]}
vidpseltfvqeigsgqfglvhlgywlnkdkvaiktiregamseedfieeaevmmklshp
klvqlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayleea
cvihrdlaarnclvgenqvikvsdfgmtrfvlddqetsstgtkfpvkwaspevfsfsrys
sksdvwsfgvlmwevfsegkipyenrsnsevvedistgfrlykprlasthvyqimnhcwk
erpedrpafsrllrqlaeiaesg

Sequence, based on observed residues (ATOM records): (download)

>d4ppaa1 d.144.1.7 (A:357-619) Tyrosine-protein kinase Itk/Tsk {Human (Homo sapiens) [TaxId: 9606]}
vidpseltfvqeigsgqfglvhlgywlnkdkvaiktiedfieeaevmmklshpklvqlyg
vcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayleeacvihrdl
aarnclvgenqvikvsdfgpvkwaspevfsfsryssksdvwsfgvlmwevfsegkipyen
rsnsevvedistgfrlykprlasthvyqimnhcwkerpedrpafsrllrqlaeiaesg

SCOPe Domain Coordinates for d4ppaa1:

Click to download the PDB-style file with coordinates for d4ppaa1.
(The format of our PDB-style files is described here.)

Timeline for d4ppaa1:

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Domains from same chain:
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d4ppaa2