Lineage for d4otra_ (4otr A:)

  1. Root: SCOPe 2.05
  2. 1886641Class d: Alpha and beta proteins (a+b) [53931] (381 folds)
  3. 1929110Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1929111Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1929232Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 1931583Protein automated matches [190091] (12 species)
    not a true protein
  7. 1931656Species Human (Homo sapiens) [TaxId:9606] [188447] (553 PDB entries)
  8. 1931880Domain d4otra_: 4otr A: [267139]
    automated match to d3pj2a_
    complexed with 2v3, dms

Details for d4otra_

PDB Entry: 4otr (more details), 1.95 Å

PDB Description: crystal structure of btk kinase domain complexed with 6-cyclopropyl-2- [3-[5-[[5-(4-ethylpiperazin-1-yl)-2-pyridyl]amino]-1-methyl-6-oxo-3- pyridyl]-2-(hydroxymethyl)phenyl]-8-fluoro-isoquinolin-1-one
PDB Compounds: (A:) Tyrosine-protein kinase BTK

SCOPe Domain Sequences for d4otra_:

Sequence; same for both SEQRES and ATOM records: (download)

>d4otra_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmnlshe
klvqlygvctkqrpifiiteymangcllnylrearhafqtqqllemckdvceameylesk
qflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlmyskfs
sksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasaavytimyscwh
ekaderptfkillsnildvmdee

SCOPe Domain Coordinates for d4otra_:

Click to download the PDB-style file with coordinates for d4otra_.
(The format of our PDB-style files is described here.)

Timeline for d4otra_: