Lineage for d1fb7a_ (1fb7 A:)

  1. Root: SCOPe 2.08
  2. 2739516Class b: All beta proteins [48724] (180 folds)
  3. 2799129Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 2799130Superfamily b.50.1: Acid proteases [50630] (4 families) (S)
  5. 2799131Family b.50.1.1: Retroviral protease (retropepsin) [50631] (9 proteins)
    dimer of identical mono-domain chains, each containing (6,10) barrel
  6. 2799147Protein Human immunodeficiency virus type 1 protease [50632] (9 species)
  7. 2799397Species Human immunodeficiency virus type 1 [TaxId:11676] [50633] (590 PDB entries)
    Uniprot P35963 57-155 ! Uniprot P04587 69-167 ! Uniprot P03366 69-167 ! Uniprot P03367 69-167 ! Uniprot P03368 69-167
  8. 2800343Domain d1fb7a_: 1fb7 A: [26683]
    complexed with roc; mutant

Details for d1fb7a_

PDB Entry: 1fb7 (more details), 2.6 Å

PDB Description: crystal structure of an in vivo hiv-1 protease mutant in complex with saquinavir: insights into the mechanisms of drug resistance
PDB Compounds: (A:) hiv-1 protease

SCOPe Domain Sequences for d1fb7a_:

Sequence; same for both SEQRES and ATOM records: (download)

>d1fb7a_ b.50.1.1 (A:) Human immunodeficiency virus type 1 protease {Human immunodeficiency virus type 1 [TaxId: 11676]}
pqvtlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmivgiggfikvrqyd
qilieicghkaigtvlvgptpvniigrnlmtqigctlnf

SCOPe Domain Coordinates for d1fb7a_:

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Timeline for d1fb7a_: