SCOPe 2.05: Domain d4mwbb1: 4mwb B:-4-606

Lineage for d4mwbb1 (4mwb B:-4-606)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.26: Adenine nucleotide alpha hydrolase-like [52373] (3 superfamilies)
   core: 3 layers, a/b/a ; parallel beta-sheet of 5 strands, order 32145

4. Superfamily c.26.1: Nucleotidylyl transferase [52374] (6 families)

5. Family c.26.1.0: automated matches [191377] (1 protein)
   not a true family

6. Protein automated matches [190459] (41 species)
   not a true protein

7. Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [188998] (16 PDB entries)

8. Domain d4mwbb1: 4mwb B:-4-606 [266823]
   Other proteins in same PDB: d4mwba2, d4mwbb2
   automated match to d4mvyb2
   protein/RNA complex; complexed with 2ek, dms, gol, met, so4

Details for d4mwbb1

PDB Entry: 4mwb, 2.31 Å

PDB Description: Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-(3-{[(2,5-dichlorothiophen-3-yl)methyl]amino}propyl)-3-thiophen-3-ylurea (Chem 1509)

PDB Compounds: (B:) Methionyl-tRNA synthetase

SCOPe Domain Sequences for d4mwbb1:

Sequence, based on SEQRES records:

>d4mwbb1 c.26.1.0 (B:-4-606) automated matches {Trypanosome (Trypanosoma brucei) [TaxId: 5691]}
gpgsmkvekvffvtspiyyvnaaphighvystlitdvigryhrvkgervfaltgtdehgq
kvaeaakqkqvspydfttavagefkkcfeqmdysidyfirttneqhkavvkelwtkleqk
gdiylgryegwysisdesfltpqnitdgvdkdgnpckvslesghvvtwvseenymfrlsa
frerllewyhanpgcivpefrrreviravekglpdlsvsraratlhnwaipvpgnpdhcv
yvwldaltnyltgsrlrvdesgkevslvddfnelerfpadvhvigkdilkfhaiywpafl
lsaglplpkkivahgwwtkdrkkiskslgnvfdpvekaeefgydalkyfllresgfsddg
dysdknmiarlngel

Sequence, based on observed residues (ATOM records):

>d4mwbb1 c.26.1.0 (B:-4-606) automated matches {Trypanosome (Trypanosoma brucei) [TaxId: 5691]}
gpgsmkvekvffvtspiyyvnaaphighvystlitdvigryhrvkgervfaltgtdehgq
kvaeaakqkqvspydfttavagefkkcfeqmdysidyfirttneqhkavvkelwtkleqk
gdiylgryegwysisdesfltpqnitdgvdnpckvslesghvvtwvseenymfrlsafre
rllewyhanpgcivpefrrreviravekglpdlsvsraratlhnwaipvpgnpdhcvyvw
ldaltnyltgsrlrvdesgkevslvddfnelerfpadvhvigkdilkfhaiywpafllsa
glplpkkivahgwwtkdrkkiskslgnvfdpvekaeefgydalkyfllresgfsddgdys
dknmiarlngel

Timeline for d4mwbb1:

• d4mwbb1 is new in SCOPe 2.05-stable
  
• d4mwbb1 appears in SCOPe 2.06
  
• d4mwbb1 appears in the current release, SCOPe 2.08