SCOPe 2.08: Domain d4mw7a2: 4mw7 A:607-767

Lineage for d4mw7a2 (4mw7 A:607-767)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.27: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47322] (1 superfamily)
   core: 4 helices; bundle; one loop crosses over one side of the bundle

4. Superfamily a.27.1: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases [47323] (2 families)

5. Family a.27.1.0: automated matches [227164] (1 protein)
   not a true family

6. Protein automated matches [226872] (13 species)
   not a true protein

7. Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [226413] (15 PDB entries)

8. Domain d4mw7a2: 4mw7 A:607-767 [266814]
   Other proteins in same PDB: d4mw7a1, d4mw7b1, d4mw7b3
   automated match to d4mvyb1
   protein/RNA complex; complexed with 2ef, dms, gol, met, so4

Details for d4mw7a2

PDB Entry: 4mw7, 2.75 Å

PDB Description: Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(5-chloro-2-ethoxy-3-iodobenzyl)amino]propyl}-3-thiophen-3-ylurea (Chem 1469)

PDB Compounds: (A:) Methionyl-tRNA synthetase

SCOPe Domain Sequences for d4mw7a2:

Sequence, based on SEQRES records:

>d4mw7a2 a.27.1.0 (A:607-767) automated matches {Trypanosome (Trypanosoma brucei) [TaxId: 5691]}
adtlgnlvmrctsakinvngewpspaayteedesliqlikdlpgtadhyylipdiqkaii
avfdvlrainayvtdmapwklvktdperlrtvlyitlegvrvttlllspilprksvvifd
mlgvpevhrkgienfefgavppgtrlgpavegevlfskrst

Sequence, based on observed residues (ATOM records):

>d4mw7a2 a.27.1.0 (A:607-767) automated matches {Trypanosome (Trypanosoma brucei) [TaxId: 5691]}
adtlgnlvmrctsakinvngewpspaayteedesliqlikdlpgtadhyylipdiqkaii
avfdvlrainayvtdmapwklvktdperlrtvlyitlegvrvttlllspilprksvvifd
mlgvpevhrkgienfefgavppgtrlgpavgevlfskrst

Timeline for d4mw7a2:

• d4mw7a2 first appeared in SCOPe 2.05
  
• d4mw7a2 appears in SCOPe 2.07