SCOP 1.65: Domain d1hpsa_: 1hps A:

Lineage for d1hpsa_ (1hps A:)

1. Root: SCOP 1.65

2. Class b: All beta proteins [48724] (126 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (2 families)

5. Family b.50.1.1: Retroviral protease (retropepsin) [50631] (8 proteins)
   dimer of identical mono-domain chains, each containing (6,10) barrel

6. Protein Human immunodeficiency virus type 1 protease [50632] (1 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [50633] (152 PDB entries)

8. Domain d1hpsa_: 1hps A: [26674]

Details for d1hpsa_

PDB Entry: 1hps, 2.3 Å

PDB Description: rational design, synthesis and crystallographic analysis of a hydroxyethylene-based hiv-1 protease inhibitor containing a heterocyclic p1'-p2' amide bond isostere

SCOP Domain Sequences for d1hpsa_:

Sequence; same for both SEQRES and ATOM records:

>d1hpsa_ b.50.1.1 (A:) Human immunodeficiency virus type 1 protease {Human immunodeficiency virus type 1}
pqitlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
qilieicghkaigtvlvgptpvniigrnlltqigctlnf

Timeline for d1hpsa_:

• d1hpsa_ first appeared (with stable ids) in SCOP 1.55
  
• d1hpsa_ appears in SCOP 1.63
  
• d1hpsa_ appears in SCOP 1.67
  
• d1hpsa_ appears in the current release, SCOPe 2.08