SCOPe 2.01: Domain d1a8kd_: 1a8k D:

Lineage for d1a8kd_ (1a8k D:)

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.1: Retroviral protease (retropepsin) [50631] (9 proteins)
   dimer of identical mono-domain chains, each containing (6,10) barrel

6. Protein Human immunodeficiency virus type 1 protease [50632] (5 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [50633] (378 PDB entries)
   Uniprot P35963 57-155 ! Uniprot P04587 69-167 ! Uniprot P03366 69-167 ! Uniprot P03367 69-167 ! Uniprot P03368 69-167

8. Domain d1a8kd_: 1a8k D: [26627]
   complexed with 0q4

Details for d1a8kd_

PDB Entry: 1a8k, 2 Å

PDB Description: crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved ca-p2 substrate: interactions with frequently occurring glutamic acid residue at p2' position of substrates

PDB Compounds: (D:) hiv protease

SCOPe Domain Sequences for d1a8kd_:

Sequence; same for both SEQRES and ATOM records:

>d1a8kd_ b.50.1.1 (D:) Human immunodeficiency virus type 1 protease {Human immunodeficiency virus type 1 [TaxId: 11676]}
pqitlwkrplvtikiggqlkealldtgaddtvieemslpgrwkpkmiggiggfikvrqyd
qiiieicghkaigtvlvgptpvniigrnlltqigctlnf

Timeline for d1a8kd_:

• d1a8kd_ first appeared (with stable ids) in SCOP 1.55
  
• d1a8kd_ appears in SCOP 1.75
  
• d1a8kd_ appears in SCOPe 2.02
  
• d1a8kd_ appears in the current release, SCOPe 2.08