SCOPe 2.06: Domain d3ptaa5: 3pta A:1135-1600

Lineage for d3ptaa5 (3pta A:1135-1600)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (60 families)

5. Family c.66.1.26: C5 cytosine-specific DNA methylase, DCM [88786] (5 proteins)
   automatically mapped to Pfam PF00145

6. Protein Methyltransferase domain from DNA methyltransferase 1 (DNMT1) [267659] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [267738] (1 PDB entry)

8. Domain d3ptaa5: 3pta A:1135-1600 [265231]
   Other proteins in same PDB: d3ptaa1, d3ptaa2, d3ptaa3, d3ptaa4
   protein/DNA complex; complexed with sah, zn

Details for d3ptaa5

PDB Entry: 3pta, 3.6 Å

PDB Description: Crystal structure of human DNMT1(646-1600) in complex with DNA

PDB Compounds: (A:) DNA (cytosine-5)-methyltransferase 1

SCOPe Domain Sequences for d3ptaa5:

Sequence, based on SEQRES records:

>d3ptaa5 c.66.1.26 (A:1135-1600) Methyltransferase domain from DNA methyltransferase 1 (DNMT1) {Human (Homo sapiens) [TaxId: 9606]}
klpklrtldvfsgcgglsegfhqagisdtlwaiemwdpaaqafrlnnpgstvftedcnil
lklvmagettnsrgqrlpqkgdvemlcggppcqgfsgmnrfnsrtyskfknslvvsflsy
cdyyrprffllenvrnfvsfkrsmvlkltlrclvrmgyqctfgvlqagqygvaqtrrrai
ilaaapgeklplfpeplhvfapracqlsvvvddkkfvsnitrlssgpfrtitvrdtmsdl
pevrngasaleisyngepqswfqrqlrgaqyqpilrdhickdmsalvaarmrhiplapgs
dwrdlpnievrlsdgtmarklrythhdrkngrsssgalrgvcscveagkacdpaarqfnt
lipwclphtgnrhnhwaglygrlewdgffsttvtnpepmgkqgrvlhpeqhrvvsvreca
rsqgfpdtyrlfgnildkhrqvgnavppplakaigleiklcmlaka

Sequence, based on observed residues (ATOM records):

>d3ptaa5 c.66.1.26 (A:1135-1600) Methyltransferase domain from DNA methyltransferase 1 (DNMT1) {Human (Homo sapiens) [TaxId: 9606]}
klpklrtldvfsgcgglsegfhqagisdtlwaiemwdpaaqafrlnnpgstvftedcnil
lklvmagettnsrgqrlpqkgdvemlcggppcqgfsgmnrfnsrtyskfknslvvsflsy
cdyyrprffllenvrnfvsfkrsmvlkltlrclvrmgyqctfgvlqagqygvaqtrrrai
ilaaapgeklplfpeplhvfapracqlsvvvddkkfvsnitrlssgpfrtitvrdtmsdl
pevrngasaleisyngepqswfqrqlrgaqyqpilrdhickdmsalvaarmrhiplapgs
dwrdlpnievrlsdgtmarklrythhdrkngrsssgalrgvcscvacdpaarqfntlipw
clphtgnrhnhwaglygrlewdgffsttvtnpepmgkqgrvlhpeqhrvvsvrecarsqg
fpdtyrlfgnildkhrqvgnavppplakaigleiklcmlaka

Timeline for d3ptaa5:

• d3ptaa5 first appeared in SCOPe 2.05
  
• d3ptaa5 appears in SCOPe 2.07
  
• d3ptaa5 appears in the current release, SCOPe 2.08