SCOPe 2.06: Domain d1difa_: 1dif A:

Lineage for d1difa_ (1dif A:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.1: Retroviral protease (retropepsin) [50631] (9 proteins)
   dimer of identical mono-domain chains, each containing (6,10) barrel

6. Protein Human immunodeficiency virus type 1 protease [50632] (9 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [50633] (476 PDB entries)
   Uniprot P35963 57-155 ! Uniprot P04587 69-167 ! Uniprot P03366 69-167 ! Uniprot P03367 69-167 ! Uniprot P03368 69-167

8. Domain d1difa_: 1dif A: [26503]
   complexed with a85, bme

Details for d1difa_

PDB Entry: 1dif, 1.7 Å

PDB Description: hiv-1 protease in complex with a difluoroketone containing inhibitor a79285

PDB Compounds: (A:) hiv-1 protease

SCOPe Domain Sequences for d1difa_:

Sequence; same for both SEQRES and ATOM records:

>d1difa_ b.50.1.1 (A:) Human immunodeficiency virus type 1 protease {Human immunodeficiency virus type 1 [TaxId: 11676]}
pqitlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
qilieicghkaigtvlvgptpvniigrnlltqigctlnf

Timeline for d1difa_:

• d1difa_ first appeared (with stable ids) in SCOP 1.55
  
• d1difa_ appears in SCOPe 2.05
  
• d1difa_ appears in SCOPe 2.07
  
• d1difa_ appears in the current release, SCOPe 2.08