SCOPe 2.08: Domain d2xasa2: 2xas A:274-654,A:764-836

Lineage for d2xasa2 (2xas A:274-654,A:764-836)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.3: FAD/NAD(P)-binding domain [51904] (1 superfamily)
   core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander

4. Superfamily c.3.1: FAD/NAD(P)-binding domain [51905] (9 families)

5. Family c.3.1.2: FAD-linked reductases, N-terminal domain [51913] (18 proteins)
   C-terminal domain is alpha+beta is common for the family

6. Protein Lysine-specific histone demethylase 1, LSD1 [159432] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [159433] (27 PDB entries)
   Uniprot O60341 274-654,764-836

8. Domain d2xasa2: 2xas A:274-654,A:764-836 [264588]
   Other proteins in same PDB: d2xasa1, d2xasa3, d2xasb1, d2xasb2
   complexed with fad, m80

Details for d2xasa2

PDB Entry: 2xas, 3.2 Å

PDB Description: crystal structure of lsd1-corest in complex with a tranylcypromine derivative (mc2580, 14e)

PDB Compounds: (A:) Lysine-specific histone demethylase 1

SCOPe Domain Sequences for d2xasa2:

Sequence; same for both SEQRES and ATOM records:

>d2xasa2 c.3.1.2 (A:274-654,A:764-836) Lysine-specific histone demethylase 1, LSD1 {Human (Homo sapiens) [TaxId: 9606]}
ptkktgkviiigsgvsglaaarqlqsfgmdvtlleardrvggrvatfrkgnyvadlgamv
vtglggnpmavvskqvnmelakikqkcplyeangqavpkekdemveqefnrlleatsyls
hqldfnvlnnkpvslgqalevviqlqekhvkdeqiehwkkivktqeelkellnkmvnlke
kikelhqqykeasevkpprditaeflvkskhrdltalckeydelaetqgkleeklqelea
nppsdvylssrdrqildwhfanlefanatplstlslkhwdqdddfeftgshltvrngysc
vpvalaegldiklntavrqvrytasgceviavntrstsqtfiykcdavlctlplgvlkqq
ppavqfvpplpewktsavqrmXvaagssgndydlmaqpitpgpsipgapqpiprlffage
htirnypatvhgallsglreagriadqflgamytl

Timeline for d2xasa2:

• d2xasa2 first appeared in SCOPe 2.05
  
• d2xasa2 appears in SCOPe 2.07