Lineage for d4ohlb2 (4ohl B:111-218)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2530460Fold d.93: SH2-like [55549] (1 superfamily)
    3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flanked by two helices
  4. 2530461Superfamily d.93.1: SH2 domain [55550] (2 families) (S)
  5. 2530930Family d.93.1.0: automated matches [191409] (1 protein)
    not a true family
  6. 2530931Protein automated matches [190561] (4 species)
    not a true protein
  7. 2530932Species Human (Homo sapiens) [TaxId:9606] [187549] (76 PDB entries)
  8. 2530967Domain d4ohlb2: 4ohl B:111-218 [263289]
    Other proteins in same PDB: d4ohla3, d4ohlb3
    automated match to d3ps5a2
    mutant

Details for d4ohlb2

PDB Entry: 4ohl (more details), 2.4 Å

PDB Description: LEOPARD Syndrome-Associated SHP2/T468M mutant
PDB Compounds: (B:) Tyrosine-protein phosphatase non-receptor type 11

SCOPe Domain Sequences for d4ohlb2:

Sequence, based on SEQRES records: (download)

>d4ohlb2 d.93.1.0 (B:111-218) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rwfhghlsgkeaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthv
mircqelkydvgggerfdsltdlvehykknpmvetlgtvlqlkqplnt

Sequence, based on observed residues (ATOM records): (download)

>d4ohlb2 d.93.1.0 (B:111-218) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rwfhghlsgkeaeklltekgkhgsflvresqshpgdfvlsvrtgskvthvmircqelkyd
vgggerfdsltdlvehykknpmvetlgtvlqlkqplnt

SCOPe Domain Coordinates for d4ohlb2:

Click to download the PDB-style file with coordinates for d4ohlb2.
(The format of our PDB-style files is described here.)

Timeline for d4ohlb2: