SCOPe 2.08: Domain d4m3pd_: 4m3p D:

Lineage for d4m3pd_ (4m3p D:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.26: Homocysteine S-methyltransferase [82282] (1 family)

5. Family c.1.26.1: Homocysteine S-methyltransferase [82283] (2 proteins)
   Pfam PF02574

6. Protein Betaine-homocysteine S-methyltransferase [82284] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [82285] (3 PDB entries)

8. Domain d4m3pd_: 4m3p D: [263001]
   automated match to d1umyc_
   complexed with hcs, k, srt, zn

Details for d4m3pd_

PDB Entry: 4m3p, 1.9 Å

PDB Description: Betaine-Homocysteine S-Methyltransferase from Homo sapiens complexed with Homocysteine

PDB Compounds: (D:) Betaine--homocysteine S-methyltransferase 1

SCOPe Domain Sequences for d4m3pd_:

Sequence, based on SEQRES records:

>d4m3pd_ c.1.26.1 (D:) Betaine-homocysteine S-methyltransferase {Human (Homo sapiens) [TaxId: 9606]}
kkgilerlnageivigdggfvfalekrgyvkagpwtpeaavehpeavrqlhreflragsn
vmqtftfyasedklenrgnyvlekisgqevneaacdiarqvadegdalvaggvsqtpsyl
scksetevkkvflqqlevfmkknvdfliaeyfehveeavwavetliasgkpvaatmcigp
egdlhgvppgecavrlvkagasiigvnchfdptislktvklmkegleaaqlkahlmsqpl
ayhtpdcnkqgfidlpefpfgleprvatrwdiqkyareaynlgvryiggccgfepyhira
iaeelapergflppasekhgswgsgldmhtkpwvrararkeywenlriasgrpynpsmsk
pdgwgvtkgtaelmqqkeatteqqlkelfekqkf

Sequence, based on observed residues (ATOM records):

>d4m3pd_ c.1.26.1 (D:) Betaine-homocysteine S-methyltransferase {Human (Homo sapiens) [TaxId: 9606]}
kkgilerlnageivigdggfvfalekrgyvkagpwtpeaavehpeavrqlhreflragsn
vmqtftfysgqevneaacdiarqvadegdalvaggvsqtpsylscksetevkkvflqqle
vfmkknvdfliaeyfehveeavwavetliasgkpvaatmcigpegdlhgvppgecavrlv
kagasiigvnchfdptislktvklmkegleaaqlkahlmsqplayhtpdcnkqgfidlpe
fpfgleprvatrwdiqkyareaynlgvryiggccgfepyhiraiaeelapergflppase
khgswgsgldmhtkpwvrararkeywenlriasgrpynpsmskpdgwaelmqqkeatteq
qlkelfekqkf

Timeline for d4m3pd_:

• d4m3pd_ first appeared in SCOPe 2.05
  
• d4m3pd_ appears in SCOPe 2.07