SCOPe 2.06: Domain d2a6ib3: 2a6i B:1-121

Lineage for d2a6ib3 (2a6i B:1-121)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (22 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 1 [TaxId:10090] [88548] (68 PDB entries)
   Uniprot P01796 # ! HV27_MOUSE Ig heavy chain V-III region A4

8. Domain d2a6ib3: 2a6i B:1-121 [262190]
   Other proteins in same PDB: d2a6ib2

Details for d2a6ib3

PDB Entry: 2a6i, 2.5 Å

PDB Description: crystal structure analysis of the anti-arsonate germline antibody 36- 65 in complex with a phage display derived dodecapeptide klasipthtspl

PDB Compounds: (B:) Germline antibody 36-65 Fab heavy chain

SCOPe Domain Sequences for d2a6ib3:

Sequence; same for both SEQRES and ATOM records:

>d2a6ib3 b.1.1.1 (B:1-121) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 1 [TaxId: 10090]}
evqlqqsgaelvragssvkmsckasgytftsyginwvkqrpgqglewigyinpgngytky
nekfkgkttltvdkssstaymqlrsltsedsavyfcarsvyyggsyyfdywgqgttltvs
s

Timeline for d2a6ib3:

• d2a6ib3 first appeared in SCOPe 2.05
  
• d2a6ib3 appears in SCOPe 2.07
  
• d2a6ib3 appears in the current release, SCOPe 2.08