SCOPe 2.05: Domain d1y8pa3: 1y8p A:174-401

Lineage for d1y8pa3 (1y8p A:174-401)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (5 families)

5. Family d.122.1.4: alpha-ketoacid dehydrogenase kinase, C-terminal domain [69804] (3 proteins)

6. Protein Pyruvate dehydrogenase kinase [69807] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [160702] (5 PDB entries)
   Uniprot Q15120 177-301

8. Domain d1y8pa3: 1y8p A:174-401 [262182]
   Other proteins in same PDB: d1y8pa1, d1y8pb_
   automated match to d2pnrb2
   complexed with atp, k, mg, red

Details for d1y8pa3

PDB Entry: 1y8p, 2.63 Å

PDB Description: Crystal structure of the PDK3-L2 complex

PDB Compounds: (A:) [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3

SCOPe Domain Sequences for d1y8pa3:

Sequence, based on SEQRES records:

>d1y8pa3 d.122.1.4 (A:174-401) Pyruvate dehydrogenase kinase {Human (Homo sapiens) [TaxId: 9606]}
gdtnpvhpkhigsidptcnvadvvkdayetakmlceqyylvapeleveefnakapdkpiq
vvyvpshlfhmlfelfknsmratvelyedrkegypavktlvtlgkedlsikisdlgggvp
lrkidrlfnymystaprpsleptraaplagfgyglpisrlyaryfqgdlklysmegvgtd
aviylkalssesferlpvfnksawrhykttpeaddwsnpsseprdask

Sequence, based on observed residues (ATOM records):

>d1y8pa3 d.122.1.4 (A:174-401) Pyruvate dehydrogenase kinase {Human (Homo sapiens) [TaxId: 9606]}
gdtnpvhpkhigsidptcnvadvvkdayetakmlceqyylvapeleveefnakapdkpiq
vvyvpshlfhmlfelfknsmratvelyedrkegypavktlvtlgkedlsikisdlgggvp
lrkidrlfnymystaprplagfgyglpisrlyaryfqgdlklysmegvgtdaviylkals
sesferlpvfnksawrhykttpeaddwsnpsseprdask

Timeline for d1y8pa3:

• d1y8pa3 is new in SCOPe 2.05-stable
  
• d1y8pa3 appears in SCOPe 2.06
  
• d1y8pa3 appears in the current release, SCOPe 2.08