SCOPe 2.08: Domain d4wwna4: 4wwn A:726-1088

Lineage for d4wwna4 (4wwn A:726-1088)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain [56171] (2 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K), catalytic domain [56172] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56174] (78 PDB entries)

8. Domain d4wwna4: 4wwn A:726-1088 [262151]
   Other proteins in same PDB: d4wwna1, d4wwna2, d4wwna3
   automated match to d1e7ua4
   complexed with 3vc, so4

Details for d4wwna4

PDB Entry: 4wwn, 2.7 Å

PDB Description: crystal structure of human pi3k-gamma in complex with (s)-n-(1-(7- fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9h-purin-6-amine amg319 inhibitor

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d4wwna4:

Sequence, based on SEQRES records:

>d4wwna4 d.144.1.4 (A:726-1088) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidf
ghilgnyksflginkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtn
lliilfsmmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfn
wfl

Sequence, based on observed residues (ATOM records):

>d4wwna4 d.144.1.4 (A:726-1088) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsdvssqvisqlkqklenlqnsqlpesfrvpydp
glkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilr
imesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnh
wlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghik
ervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmp
qltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwfl

Timeline for d4wwna4:

• d4wwna4 first appeared in SCOPe 2.04
  
• d4wwna4 appears in SCOPe 2.07