SCOPe 2.05: Domain d4wwna2: 4wwn A:352-522

Lineage for d4wwna2 (4wwn A:352-522)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.7: C2 domain-like [49561] (5 superfamilies)
   sandwich; 8 strands in 2 sheets; greek-key

4. Superfamily b.7.1: C2 domain (Calcium/lipid-binding domain, CaLB) [49562] (3 families)
   two constituent families are related by circular permutation

5. Family b.7.1.1: PLC-like (P variant) [49563] (12 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K) [49570] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [49572] (57 PDB entries)

8. Domain d4wwna2: 4wwn A:352-522 [262147]
   Other proteins in same PDB: d4wwna1, d4wwna3, d4wwna4
   automated match to d1e8wa2
   complexed with 3vc, so4

Details for d4wwna2

PDB Entry: 4wwn, 2.7 Å

PDB Description: crystal structure of human pi3k-gamma in complex with (s)-n-(1-(7- fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9h-purin-6-amine amg319 inhibitor

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d4wwna2:

Sequence, based on SEQRES records:

>d4wwna2 b.7.1.1 (A:352-522) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
vslwdcdrkfrvkirgidipvlprntdltvfveaniqhgqqvlcqrrtspkpfteevlwn
vwlefsikikdlpkgallnlqiycgkapalsskasaespsseskgkvqllyyvnlllidh
rfllrrgeyvlhmwqisgkgedqgsfnadkltsatnpdkensmsisilldn

Sequence, based on observed residues (ATOM records):

>d4wwna2 b.7.1.1 (A:352-522) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
vslwdcdrkfrvkirgidipvlltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlef
sikikdlpkgallnlqiycgkvqllyyvnlllidhrfllrrgeyvlhmwqissfnadklt
satnpdkensmsisilldn

Timeline for d4wwna2:

• d4wwna2 first appeared in SCOPe 2.04
  
• d4wwna2 appears in SCOPe 2.06
  
• d4wwna2 appears in the current release, SCOPe 2.08