SCOPe 2.05: Domain d4wwna1: 4wwn A:144-321

Lineage for d4wwna1 (4wwn A:144-321)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.15: beta-Grasp (ubiquitin-like) [54235] (14 superfamilies)
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

4. Superfamily d.15.1: Ubiquitin-like [54236] (9 families)

5. Family d.15.1.5: Ras-binding domain, RBD [54263] (14 proteins)
   contains Pfam PF00788 and Pfam PF02196

6. Protein Phoshoinositide 3-kinase (PI3K) [54274] (2 species)
   includes parts of the flanking linkers

7. Species Human (Homo sapiens) [TaxId:9606] [54276] (58 PDB entries)

8. Domain d4wwna1: 4wwn A:144-321 [262146]
   Other proteins in same PDB: d4wwna2, d4wwna3, d4wwna4
   automated match to d1e7ua3
   complexed with 3vc, so4

Details for d4wwna1

PDB Entry: 4wwn, 2.7 Å

PDB Description: crystal structure of human pi3k-gamma in complex with (s)-n-(1-(7- fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9h-purin-6-amine amg319 inhibitor

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d4wwna1:

Sequence, based on SEQRES records:

>d4wwna1 d.15.1.5 (A:144-321) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdipe
sqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrke

Sequence, based on observed residues (ATOM records):

>d4wwna1 d.15.1.5 (A:144-321) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgaidfvlrvcgrdeylvgetpi
knfqwvrhclkngeeihvvldtppdpaldevrke

Timeline for d4wwna1:

• d4wwna1 first appeared in SCOPe 2.04
  
• d4wwna1 appears in SCOPe 2.06
  
• d4wwna1 appears in the current release, SCOPe 2.08