Lineage for d4wwpa4 (4wwp A:726-1090)

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2195565Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2195566Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2195572Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain [56171] (1 protein)
  6. 2195573Protein Phoshoinositide 3-kinase (PI3K), catalytic domain [56172] (2 species)
  7. 2195574Species Human (Homo sapiens) [TaxId:9606] [56174] (65 PDB entries)
  8. 2195594Domain d4wwpa4: 4wwp A:726-1090 [262145]
    Other proteins in same PDB: d4wwpa1, d4wwpa2, d4wwpa3
    automated match to d1e7ua4
    complexed with 3ve, gol, so4

Details for d4wwpa4

PDB Entry: 4wwp (more details), 2.4 Å

PDB Description: crystal structure of human pi3k-gamma in complex with pyridinylquinoline inhibitor n-{(1s)-1-[8-chloro-2-(2-methylpyridin- 3-yl)quinolin-3-yl]ethyl}-9h-purin-6-amine
PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d4wwpa4:

Sequence, based on SEQRES records: (download)

>d4wwpa4 d.144.1.4 (A:726-1090) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidf
ghilgnyksflginkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtn
lliilfsmmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfn
wflhl

Sequence, based on observed residues (ATOM records): (download)

>d4wwpa4 d.144.1.4 (A:726-1090) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsdvssqvisqlkqklenlqnsqlpesfrvpydp
glkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilr
imesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnh
wlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghik
ervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmp
tskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhl

SCOPe Domain Coordinates for d4wwpa4:

Click to download the PDB-style file with coordinates for d4wwpa4.
(The format of our PDB-style files is described here.)

Timeline for d4wwpa4: