Lineage for d4wwpa2 (4wwp A:352-522)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2038038Fold b.7: C2 domain-like [49561] (5 superfamilies)
    sandwich; 8 strands in 2 sheets; greek-key
  4. 2038039Superfamily b.7.1: C2 domain (Calcium/lipid-binding domain, CaLB) [49562] (3 families) (S)
    two constituent families are related by circular permutation
  5. 2038040Family b.7.1.1: PLC-like (P variant) [49563] (12 protein domains)
  6. 2038063Protein Phoshoinositide 3-kinase (PI3K) [49570] (2 species)
  7. 2038064Species Human (Homo sapiens) [TaxId:9606] [49572] (58 PDB entries)
  8. 2038084Domain d4wwpa2: 4wwp A:352-522 [262143]
    Other proteins in same PDB: d4wwpa1, d4wwpa3, d4wwpa4
    automated match to d1e8wa2
    complexed with 3ve, gol, so4

Details for d4wwpa2

PDB Entry: 4wwp (more details), 2.4 Å

PDB Description: Crystal structure of human PI3K-gamma in complex with pyridinylquinoline inhibitor N-{(1S)-1-[8-chloro-2-(2-methylpyridin-3-yl)quinolin-3-yl]ethyl}-9H-purin-6-amine
PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d4wwpa2:

Sequence, based on SEQRES records: (download)

>d4wwpa2 b.7.1.1 (A:352-522) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}

Sequence, based on observed residues (ATOM records): (download)

>d4wwpa2 b.7.1.1 (A:352-522) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d4wwpa2:

Click to download the PDB-style file with coordinates for d4wwpa2.
(The format of our PDB-style files is described here.)

Timeline for d4wwpa2: