SCOPe 2.04: Domain d4wkgf3: 4wkg F:314-656

Lineage for d4wkgf3 (4wkg F:314-656)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Polymyxin resistance protein ArnA (PrmI) [117419] (1 species)
   evolved new activities: UDP-glucuronic acid decarboxylase, UDP-4-amino-4-deoxy-L-arabinose formyltransferase

7. Species Escherichia coli [TaxId:562] [117420] (8 PDB entries)
   Uniprot P77398

8. Domain d4wkgf3: 4wkg F:314-656 [262110]
   Other proteins in same PDB: d4wkga1, d4wkga2, d4wkgb1, d4wkgb2, d4wkgc1, d4wkgc2, d4wkgd1, d4wkgd2, d4wkge1, d4wkge2, d4wkgf1, d4wkgf2
   automated match to d1z7ea2
   complexed with act, dtt

Details for d4wkgf3

PDB Entry: 4wkg, 2.7 Å

PDB Description: the crystal structure of apo arna features an unexpected central binding pocket and provides an explanation for enzymatic coop- erativity

PDB Compounds: (F:) Bifunctional polymyxin resistance protein ArnA

SCOPe Domain Sequences for d4wkgf3:

Sequence, based on SEQRES records:

>d4wkgf3 c.2.1.2 (F:314-656) Polymyxin resistance protein ArnA (PrmI) {Escherichia coli [TaxId: 562]}
rrtrvlilgvngfignhlterllredhyevygldigsdaisrflnhphfhfvegdisihs
ewieyhvkkcdvvlplvaiatpieytrnplrvfeldfeenlriirycvkyrkriifpsts
evygmcsdkyfdedhsnlivgpvnkprwiysvskqlldrviwaygekeglqftlfrpfnw
mgprldnlnaarigssraitqlilnlvegspiklidggkqkrcftdirdgiealyriien
agnrcdgeiinignpeneasieelgemllasfekhplrhhfppfagfrvvesssyygkgy
qdvehrkpsirnahrcldwepkidmqetidetldfflrtvdlt

Sequence, based on observed residues (ATOM records):

>d4wkgf3 c.2.1.2 (F:314-656) Polymyxin resistance protein ArnA (PrmI) {Escherichia coli [TaxId: 562]}
rrtrvlilgvngfignhlterllredhyevygldigsdaisrflnhphfhfvegdisihs
ewieyhvkkcdvvlplvaiatpieytrnplrvfeldfeenlriirycvkyrkriifpsts
evygmcsdkyfdedhsnlivgpvnkprwiysvskqlldrviwaygekeglqftlfrpfnw
mgprldnlnaarigssraitqlilnlvegspiklidggkqkrcftdirdgiealyriien
agnrcdgeiinignpeneasieelgemllasfekhplrhhfppfagfrvvesssqdvehr
kpsirnahrcldwepkidmqetidetldfflrtvdlt

Timeline for d4wkgf3:

• d4wkgf3 is new in SCOPe 2.04-stable
  
• d4wkgf3 appears in SCOPe 2.05
  
• d4wkgf3 appears in the current release, SCOPe 2.08