SCOPe 2.04: Domain d4v05a_: 4v05 A:

Lineage for d4v05a_ (4v05 A:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Fibroblast growth factor receptor 1 [56158] (1 species)
   PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56159] (20 PDB entries)

8. Domain d4v05a_: 4v05 A: [262052]
   automated match to d4nkab_
   complexed with 66t, edo, so4

Details for d4v05a_

PDB Entry: 4v05, 2.57 Å

PDB Description: FGFR1 in complex with AZD4547.

PDB Compounds: (A:) fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, pfeiffer syndrome), isoform cra_b

SCOPe Domain Sequences for d4v05a_:

Sequence, based on SEQRES records:

>d4v05a_ d.144.1.7 (A:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
elpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksdatek
dlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppgley
synpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfg
lardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypg
vpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivaltsn
qe

Sequence, based on observed residues (ATOM records):

>d4v05a_ d.144.1.7 (A:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
elpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksdatek
dlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppgeeq
lsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglaridyykktt
ngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeghr
mdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivaltsnqe

Timeline for d4v05a_:

• d4v05a_ is new in SCOPe 2.04-stable
  
• d4v05a_ appears in SCOPe 2.05
  
• d4v05a_ appears in the current release, SCOPe 2.08