SCOPe 2.08: Domain d4v04b_: 4v04 B:

Lineage for d4v04b_ (4v04 B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Fibroblast growth factor receptor 1 [56158] (1 species)
   PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56159] (47 PDB entries)

8. Domain d4v04b_: 4v04 B: [262048]
   automated match to d4nkab_
   complexed with 0li, edo, so4

Details for d4v04b_

PDB Entry: 4v04, 2.12 Å

PDB Description: fgfr1 in complex with ponatinib.

PDB Compounds: (B:) fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, pfeiffer syndrome), isoform cra_b

SCOPe Domain Sequences for d4v04b_:

Sequence, based on SEQRES records:

>d4v04b_ d.144.1.7 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
agvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlk
sdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarr
ppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvm
kiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlg
gspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldri
valtsnqe

Sequence, based on observed residues (ATOM records):

>d4v04b_ d.144.1.7 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
agvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlk
sdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarr
ppeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglidyykk
ttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeg
hrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivaltsnqe

Timeline for d4v04b_:

• d4v04b_ first appeared in SCOPe 2.04
  
• d4v04b_ appears in SCOPe 2.07