SCOPe 2.08: Domain d4rixd_: 4rix D:

Lineage for d4rixd_ (4rix D:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (133 PDB entries)
   Uniprot P00533 702-1018

8. Domain d4rixd_: 4rix D: [261969]
   Other proteins in same PDB: d4rixa_, d4rixc_
   automated match to d3ikaa_
   complexed with adp, anp, mg; mutant

Details for d4rixd_

PDB Entry: 4rix, 3.1 Å

PDB Description: Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-Q790R mutation

PDB Compounds: (D:) Epidermal growth factor receptor

SCOPe Domain Sequences for d4rixd_:

Sequence; same for both SEQRES and ATOM records:

>d4rixd_ d.144.1.7 (D:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
lvepltpsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikel
reatspkankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkd
nigsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeek
eyhaeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissil
ekgerlpqppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgd

Timeline for d4rixd_:

• d4rixd_ first appeared in SCOPe 2.04
  
• d4rixd_ appears in SCOPe 2.07