Lineage for d4rixc_ (4rix C:)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2546221Family d.144.1.0: automated matches [191359] (1 protein)
    not a true family
  6. 2546222Protein automated matches [190417] (29 species)
    not a true protein
  7. 2546365Species Human (Homo sapiens) [TaxId:9606] [187294] (1145 PDB entries)
  8. 2547591Domain d4rixc_: 4rix C: [261682]
    Other proteins in same PDB: d4rixb_, d4rixd_
    automated match to d3kexa_
    complexed with adp, anp, mg; mutant

Details for d4rixc_

PDB Entry: 4rix (more details), 3.1 Å

PDB Description: Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-Q790R mutation
PDB Compounds: (C:) Receptor tyrosine-protein kinase erbB-3

SCOPe Domain Sequences for d4rixc_:

Sequence, based on SEQRES records: (download)

>d4rixc_ d.144.1.0 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vlarifketelrklkvlgsgvfgtvhkgvwipegesikipvcikviedksgrqsfqavtd
hmlaigsldhahivrllglcpgsslqlvtqylplgslldhvrqhrgalgprlllnwgvqi
akgmyyleehgmvhrnlaarnvllkspsqvqvadfgvadllppddkqllyseaktpikwm
alesihfgkythqsdvwsygvtvwelmtfgaepyaglrlaevpdllekgerlaqpqicti
dvymvmvkcwmidenirptfkelaneftrmardpprylvik

Sequence, based on observed residues (ATOM records): (download)

>d4rixc_ d.144.1.0 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vlarifketelrklkvlgsgvfgtvhkgvwipegesikipvcikviesfqavtdhmlaig
sldhahivrllglcpgsslqlvtqylplgslldhvrqhrgalgprlllnwgvqiakgmyy
leehgmvhrnlaarnvllkspsqvqvadfgvadllppddkqllyseaktpikwmalesih
fgkythqsdvwsygvtvwelmtfgaepyaglrlaevpdllekgerlaqpqictidvymvm
vkcwmidenirptfkelaneftrmardpprylvik

SCOPe Domain Coordinates for d4rixc_:

Click to download the PDB-style file with coordinates for d4rixc_.
(The format of our PDB-style files is described here.)

Timeline for d4rixc_: