Lineage for d4cfmc1 (4cfm C:1-296)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2542316Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2542927Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  7. 2542928Species Human (Homo sapiens) [TaxId:9606] [88856] (402 PDB entries)
    Uniprot P24941
  8. 2543380Domain d4cfmc1: 4cfm C:1-296 [261649]
    Other proteins in same PDB: d4cfma2, d4cfmb1, d4cfmb2, d4cfmc2, d4cfmd1, d4cfmd2
    automated match to d1h1pa_
    complexed with 4qe

Details for d4cfmc1

PDB Entry: 4cfm (more details), 2.85 Å

PDB Description: Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.
PDB Compounds: (C:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d4cfmc1:

Sequence, based on SEQRES records: (download)

>d4cfmc1 d.144.1.7 (C:1-296) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl

Sequence, based on observed residues (ATOM records): (download)

>d4cfmc1 d.144.1.7 (C:1-296) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpppldedgrsllsqmlhyd
pnkrisakaalahpffqdvtkpvphl

SCOPe Domain Coordinates for d4cfmc1:

Click to download the PDB-style file with coordinates for d4cfmc1.
(The format of our PDB-style files is described here.)

Timeline for d4cfmc1: