SCOPe 2.08: Domain d4cqeb_: 4cqe B:

Lineage for d4cqeb_ (4cqe B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d4cqeb_: 4cqe B: [261647]
   automated match to d4fk3a_
   complexed with cqe; mutant

Details for d4cqeb_

PDB Entry: 4cqe, 2.3 Å

PDB Description: b-raf kinase v600e mutant in complex with a diarylthiazole b-raf inhibitor

PDB Compounds: (B:) slc45a3-braf fusion protein

SCOPe Domain Sequences for d4cqeb_:

Sequence, based on SEQRES records:

>d4cqeb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrk
trhvnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtargmdyl
haksiihrdlksnniflhedntvkigdfglateksrwsgshqfeqlsgsilwmapevirm
qdsnpysfqsdvyafgivlyelmtgqlpysninnrdqiiemvgrgslspdlskvrsncpk
rmkrlmaeclkkkrderpsfprilaeieelare

Sequence, based on observed residues (ATOM records):

>d4cqeb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ddweipdgqitvgqrigsgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrktrh
vnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtargmdylhak
siihrdlksnniflhedntvkigdfggsilwmapevirnpysfqsdvyafgivlyelmtg
qlpysninnrdqiiemvgrgslspdlskvrsncpkrmkrlmaeclkkkrderpsfprila
eieelare

Timeline for d4cqeb_:

• d4cqeb_ first appeared in SCOPe 2.04
  
• d4cqeb_ appears in SCOPe 2.07