SCOPe 2.06: Domain d4cqea_: 4cqe A:

Lineage for d4cqea_ (4cqe A:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (25 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (882 PDB entries)

8. Domain d4cqea_: 4cqe A: [261646]
   automated match to d4fk3a_
   complexed with cqe; mutant

Details for d4cqea_

PDB Entry: 4cqe, 2.3 Å

PDB Description: b-raf kinase v600e mutant in complex with a diarylthiazole b-raf inhibitor

PDB Compounds: (A:) slc45a3-braf fusion protein

SCOPe Domain Sequences for d4cqea_:

Sequence, based on SEQRES records:

>d4cqea_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrkt
rhvnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtargmdylh
aksiihrdlksnniflhedntvkigdfglateksrwsgshqfeqlsgsilwmapevirmq
dsnpysfqsdvyafgivlyelmtgqlpysninnrdqiiemvgrgslspdlskvrsncpkr
mkrlmaeclkkkrderpsfprilaeieelare

Sequence, based on observed residues (ATOM records):

>d4cqea_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dweipdgqitvgqrigsggtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrktrh
vnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtargmdylhak
siihrdlksnniflhedntvkigdfggsilwmapevirmqnpysfqsdvyafgivlyelm
tgqlpysninnrdqiiemvgrgslspdlskvrsncpkrmkrlmaeclkkkrderpsfpri
laeieelare

Timeline for d4cqea_:

• d4cqea_ first appeared in SCOPe 2.04
  
• d4cqea_ appears in SCOPe 2.05
  
• d4cqea_ appears in SCOPe 2.07
  
• d4cqea_ appears in the current release, SCOPe 2.08