SCOPe 2.07: Domain d1b7x.1: 1b7x A:,B:

Lineage for d1b7x.1 (1b7x A:,B:)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein Thrombin [50531] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50532] (171 PDB entries)
   Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620

8. Domain d1b7x.1: 1b7x A:,B: [26153]
   mutant

Details for d1b7x.1

PDB Entry: 1b7x, 2.1 Å

PDB Description: structure of human alpha-thrombin y225i mutant bound to d-phe-pro-arg- chloromethylketone

PDB Compounds: (A:) protein (thrombin light chain), (B:) protein (thrombin heavy chain)

SCOPe Domain Sequences for d1b7x.1:

Sequence, based on SEQRES records:

>g1b7x.1 b.47.1.2 (A:,B:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
adcglrplfekksledkterellesyXivegsdaeigmspwqvmlfrkspqellcgasli
sdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihprynwr
enldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlketwtanvg
kgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvmks
pfnnrwyqmgivswgegcdrdgkigfythvfrlkkwiqkvidq

Sequence, based on observed residues (ATOM records):

>g1b7x.1 b.47.1.2 (A:,B:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
adcglrplfekksledkterellesyXivegsdaeigmspwqvmlfrkspqellcgasli
sdrwvltaahcllyppwdknftendllvrigkhsryerniekismlekiyihprynwren
ldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlkegqpsvlqvv
nlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmg
ivswgegcdrdgkigfythvfrlkkwiqkvidq

Timeline for d1b7x.1:

• d1b7x.1 first appeared (with stable ids) in SCOP 1.55
  
• d1b7x.1 appears in SCOPe 2.06
  
• d1b7x.1 appears in the current release, SCOPe 2.08