SCOPe 2.05: Domain d4v25a2: 4v25 A:177-366

Lineage for d4v25a2 (4v25 A:177-366)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (5 families)

5. Family d.122.1.4: alpha-ketoacid dehydrogenase kinase, C-terminal domain [69804] (3 proteins)

6. Protein automated matches [230554] (2 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [230555] (13 PDB entries)

8. Domain d4v25a2: 4v25 A:177-366 [261461]
   Other proteins in same PDB: d4v25a1
   automated match to d4mpna2
   complexed with mg, sz6, tf3

Details for d4v25a2

PDB Entry: 4v25, 2.6 Å

PDB Description: ver-246608, a novel pan-isoform atp competitive inhibitor of pyruvate dehydrogenase kinase, disrupts warburg metabolism and induces context- dependent cytostasis in cancer cells

PDB Compounds: (A:) [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

SCOPe Domain Sequences for d4v25a2:

Sequence, based on SEQRES records:

>d4v25a2 d.122.1.4 (A:177-366) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pkhigsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyvpsh
lyhmlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkierlf
symystaptpqpgtggtplagfgyglpisrlyakyfqgdlqlfsmegfgtdaviylkals
tdsverlpvy

Sequence, based on observed residues (ATOM records):

>d4v25a2 d.122.1.4 (A:177-366) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pkhigsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyvpsh
lyhmlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkierlf
symystapplagfgyglpisrlyakyfqgdlqlfsmegfgtdaviylkalstdsverlpv
y

Timeline for d4v25a2:

• d4v25a2 first appeared in SCOPe 2.04
  
• d4v25a2 appears in SCOPe 2.06
  
• d4v25a2 appears in the current release, SCOPe 2.08