SCOPe 2.04: Domain d4v25a1: 4v25 A:6-169

Lineage for d4v25a1 (4v25 A:6-169)

1. Root: SCOPe 2.04

2. Class a: All alpha proteins [46456] (285 folds)

3. Fold a.29: Bromodomain-like [47363] (15 superfamilies)
   4 helices; bundle; minor mirror variant of up-and-down topology

4. Superfamily a.29.5: alpha-ketoacid dehydrogenase kinase, N-terminal domain [69012] (2 families)
   automatically mapped to Pfam PF10436

5. Family a.29.5.1: alpha-ketoacid dehydrogenase kinase, N-terminal domain [69013] (3 proteins)

6. Protein automated matches [230549] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [230552] (13 PDB entries)

8. Domain d4v25a1: 4v25 A:6-169 [261460]
   Other proteins in same PDB: d4v25a2
   automated match to d4mpna1
   complexed with mg, sz6, tf3

Details for d4v25a1

PDB Entry: 4v25, 2.6 Å

PDB Description: ver-246608, a novel pan-isoform atp competitive inhibitor of pyruvate dehydrogenase kinase, disrupts warburg metabolism and induces context- dependent cytostasis in cancer cells

PDB Compounds: (A:) [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

SCOPe Domain Sequences for d4v25a1:

Sequence, based on SEQRES records:

>d4v25a1 a.29.5.1 (A:6-169) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gsapkyiehfskfspsplsmkqfldfgssnacektsftflrqelpvrlanimkeinllpd
rvlstpsvqlvqswyvqslldimefldkdpedhrtlsqftdalvtirnrhndvvptmaqg
vleykdtygddpvsnqniqyfldrfylsrisirmlinqhtlifd

Sequence, based on observed residues (ATOM records):

>d4v25a1 a.29.5.1 (A:6-169) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gsapkyiehfskfspsplsmkqfldfgsacektsftflrqelpvrlanimkeinllpdrv
lstpsvqlvqswyvqslldimefldkdpedhrtlsqftdalvtirnrhndvvptmaqgvl
eykdtygddpvsnqniqyfldrfylsrisirmlinqhtlifd

Timeline for d4v25a1:

• d4v25a1 is new in SCOPe 2.04-stable
  
• d4v25a1 appears in SCOPe 2.05
  
• d4v25a1 appears in the current release, SCOPe 2.08