SCOPe 2.06: Domain d4r5na1: 4r5n A:60-453

Lineage for d4r5na1 (4r5n A:60-453)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (281 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d4r5na1: 4r5n A:60-453 [261395]
   Other proteins in same PDB: d4r5na2
   automated match to d4hzta_
   complexed with 3j9, ni

Details for d4r5na1

PDB Entry: 4r5n, 1.8 Å

PDB Description: 8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d4r5na1:

Sequence, based on SEQRES records:

>d4r5na1 b.50.1.2 (A:60-453) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiigg
idhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpk
kvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfri
tilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsa
chvhdefrtaavegpfvtldmedcgynipqtdes

Sequence, based on observed residues (ATOM records):

>d4r5na1 b.50.1.2 (A:60-453) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgsevlasvggsmiiggidhslyt
gslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaav
ksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqy
lrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdef
rtaavegpfvtldmedcgynipqtdes

Timeline for d4r5na1:

• d4r5na1 first appeared in SCOPe 2.04, called d4r5na_
  
• d4r5na1 was called d4r5na_ in SCOPe 2.05
  
• d4r5na1 appears in SCOPe 2.07
  
• d4r5na1 appears in the current release, SCOPe 2.08