Lineage for d2thf.1 (2thf A:,B:)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2055629Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 2055630Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families) (S)
  5. 2055877Family b.47.1.2: Eukaryotic proteases [50514] (49 protein domains)
  6. 2056594Protein Thrombin [50531] (2 species)
  7. 2056630Species Human (Homo sapiens) [TaxId:9606] [50532] (170 PDB entries)
    Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620
  8. 2056741Domain d2thf.1: 2thf A:,B: [26139]
    complexed with 0g6, na; mutant

Details for d2thf.1

PDB Entry: 2thf (more details), 2.1 Å

PDB Description: structure of human alpha-thrombin y225f mutant bound to d-phe-pro-arg-chloromethylketone
PDB Compounds: (A:) Thrombin light chain, (B:) Thrombin heavy chain

SCOPe Domain Sequences for d2thf.1:

Sequence, based on SEQRES records: (download)

>g2thf.1 b.47.1.2 (A:,B:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
dcglrplfekksledkterellesyiXivegsdaeigmspwqvmlfrkspqellcgasli
sdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihprynwr
enldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlketwtanvg
kgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvmks
pfnnrwyqmgivswgegcdrdgkfgfythvfrlkkwiqkvidqf

Sequence, based on observed residues (ATOM records): (download)

>g2thf.1 b.47.1.2 (A:,B:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
dcglrplfekksledkterellesyiXivegsdaeigmspwqvmlfrkspqellcgasli
sdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihprynwr
enldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlkegqpsvlq
vvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyq
mgivswgegcdrdgkfgfythvfrlkkwiqkvidqf

SCOPe Domain Coordinates for d2thf.1:

Click to download the PDB-style file with coordinates for d2thf.1.
(The format of our PDB-style files is described here.)

Timeline for d2thf.1: