SCOP 1.67: Domain d1fpc.1: 1fpc L:,H:

Lineage for d1fpc.1 (1fpc L:,H:)

1. Root: SCOP 1.67

2. Class b: All beta proteins [48724] (141 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (44 proteins)

6. Protein Thrombin [50531] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50532] (149 PDB entries)

8. Domain d1fpc.1: 1fpc L:,H: [26132]
   complexed with ans, epi, so3

Details for d1fpc.1

PDB Entry: 1fpc, 2.3 Å

PDB Description: active site mimetic inhibition of thrombin

SCOP Domain Sequences for d1fpc.1:

Sequence, based on SEQRES records:

>g1fpc.1 b.47.1.2 (L:,H:) Thrombin {Human (Homo sapiens)}
dcglrplfekksledkterellesyiXivegsdaeigmspwqvmlfrkspqellcgasli
sdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihprynwr
enldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlketwtanvg
kgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvmks
pfnnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvidq

Sequence, based on observed residues (ATOM records):

>g1fpc.1 b.47.1.2 (L:,H:) Thrombin {Human (Homo sapiens)}
dcglrplfekksledkterellesyiXivegsdaeigmspwqvmlfrkspqellcgasli
sdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihprynwr
enldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlkegqpsvlq
vvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyq
mgivswgegcdrdgkygfythvfrlkkwiqkvidq

Timeline for d1fpc.1:

• d1fpc.1 first appeared (with stable ids) in SCOP 1.55
  
• d1fpc.1 appears in SCOP 1.65
  
• d1fpc.1 appears in SCOP 1.69
  
• d1fpc.1 appears in the current release, SCOPe 2.08