SCOPe 2.08: Domain d4uvra1: 4uvr A:32-476

Lineage for d4uvra1 (4uvr A:32-476)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.104: Cytochrome P450 [48263] (1 superfamily)
   multihelical

4. Superfamily a.104.1: Cytochrome P450 [48264] (2 families)

5. Family a.104.1.0: automated matches [191509] (1 protein)
   not a true family

6. Protein automated matches [190847] (99 species)
   not a true protein

7. Species Trypanosoma cruzi [TaxId:5693] [196511] (20 PDB entries)

8. Domain d4uvra1: 4uvr A:32-476 [261301]
   Other proteins in same PDB: d4uvra2
   automated match to d3khma_
   complexed with hem, j5y, so4

Details for d4uvra1

PDB Entry: 4uvr, 2.48 Å

PDB Description: Binding mode, selectivity and potency of N-indolyl-oxopyridinyl-4- amino-propanyl-based inhibitors targeting Trypanosoma cruzi CYP51

PDB Compounds: (A:) sterol 14-demethylase, cyp51

SCOPe Domain Sequences for d4uvra1:

Sequence, based on SEQRES records:

>d4uvra1 a.104.1.0 (A:32-476) automated matches {Trypanosoma cruzi [TaxId: 5693]}
ppvypvtvpflghivqfgknplefmqrckrdlksgvftisiggqrvtivgdphehsrffs
prneilsprevytimtpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiqhevr
kfmaenwkedegvinlledcgamiintacqclfgedlrkrlnarhfaqllskmesslipa
avfmpwllrlplpqsarcrearaelqkilgeiivarekeeaskdnntsdllggllkavyr
dgtrmslhevcgmivaamfagqhtstittswsmlhlmhpknkkwldklhkeidefpaqln
ydnvmdempfaercvresirrdppllmvmrmvkaevkvgsyvvpkgdiiacspllshhde
eafpnprlwdperdekvdgafigfgagvhkcigqkfallqvktilatafreydfqllrde
vpdpdyhtmvvgptlnqclvkytrk

Sequence, based on observed residues (ATOM records):

>d4uvra1 a.104.1.0 (A:32-476) automated matches {Trypanosoma cruzi [TaxId: 5693]}
ppvypvtvpflghivqfgknplefmqrckrdlksgvftisiggqrvtivgdphehsrffs
prneilsprevytimtpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiqhevr
kfmaenwkedegvinlledcgamiintacqclfgedlrkrlnarhfaqllskmesslipa
avfmpwllrlplpqsarcrearaelqkilgeiivareksdllggllkavyrdgtrmslhe
vcgmivaamfagqhtstittswsmlhlmhpknkkwldklhkeidefpaqlnydnvmdemp
faercvresirrdppllmvmrmvkaevkvgsyvvpkgdiiacspllshhdeeafpnprlw
dperdekvdgafigfgagvhkcigqkfallqvktilatafreydfqllrdevpdpdyhtm
vvgptlnqclvkytrk

Timeline for d4uvra1:

• d4uvra1 first appeared in SCOPe 2.04, called d4uvra_
  
• d4uvra1 appears in SCOPe 2.07