SCOPe 2.08: Domain d4r6va1: 4r6v A:445-750

Lineage for d4r6va1 (4r6v A:445-750)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d4r6va1: 4r6v A:445-750 [261271]
   Other proteins in same PDB: d4r6va2
   automated match to d3ky2a_
   complexed with fi3, so4; mutant

Details for d4r6va1

PDB Entry: 4r6v, 2.35 Å

PDB Description: Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex with FIIN-3, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR kinase Gate-Keeper Mutations

PDB Compounds: (A:) Fibroblast growth factor receptor 4

SCOPe Domain Sequences for d4r6va1:

Sequence, based on SEQRES records:

>d4r6va1 d.144.1.7 (A:445-750) automated matches {Human (Homo sapiens) [TaxId: 9606]}
llaglvsldlpldplwefprdrlvlgkplgegcfgqvvraeafgmdparpdqastvavkm
lkdnasdkdladlvsemevmkligrhkniinllgvctqegplyvilecaakgnlreflra
rrppgpdlspdgprssegplsfpvlvscayqvargmqylesrkcihrdlaarnvlvtedn
vmkiadfglargvhhidyykktsngrlpvkwmapealfdevythqsdvwsfgillweift
lggspypgipveelfsllreghrmdrpphcppelyglmrecwhaapsqrptfkqlveald
kvllav

Sequence, based on observed residues (ATOM records):

>d4r6va1 d.144.1.7 (A:445-750) automated matches {Human (Homo sapiens) [TaxId: 9606]}
llaglvsldlpldplwefprdrlvlgkplgegcfgqvvraeafgmdqastvavkmlkdna
sdkdladlvsemevmkligrhkniinllgvctqegplyvilecaakgnlreflrarrppg
plsfpvlvscayqvargmqylesrkcihrdlaarnvlvtednvmkiadfglapvkwmape
alfdevythqsdvwsfgillweiftlggspypgipveelfsllreghrmdrpphcppely
glmrecwhaapsqrptfkqlvealdkvllav

Timeline for d4r6va1:

• d4r6va1 first appeared in SCOPe 2.04, called d4r6va_
  
• d4r6va1 appears in SCOPe 2.07