SCOPe 2.01: Domain d1eola_: 1eol A:

Lineage for d1eola_ (1eol A:)

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (48 proteins)

6. Protein Thrombin [50531] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50532] (160 PDB entries)
   Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620

8. Domain d1eola_: 1eol A: [26126]

Details for d1eola_

PDB Entry: 1eol, 2.1 Å

PDB Description: design of p1' and p3' residues of trivalent thrombin inhibitors and their crystal structures

PDB Compounds: (A:) alpha thrombin

SCOPe Domain Sequences for d1eola_:

Sequence, based on SEQRES records:

>d1eola_ b.47.1.2 (A:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
ggadcglrplfekksledkterellesyidgrivegsdaeigmspwqvmlfrkspqellc
gaslisdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihp
rynwrenldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlketw
tanvgkgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggp
fvmkspfnnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvidqf

Sequence, based on observed residues (ATOM records):

>d1eola_ b.47.1.2 (A:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
ggadcglrplfekksledkterellesyiivegsdaeigmspwqvmlfrkspqellcgas
lisdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihpryn
wrenldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlkegqpsv
lqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvmkspfnnrw
yqmgivswgegcdrdgkygfythvfrlkkwiqkvidqf

Timeline for d1eola_:

• d1eola_ first appeared (with stable ids) in SCOP 1.55
  
• d1eola_ appears in SCOP 1.75
  
• d1eola_ appears in SCOPe 2.02
  
• d1eola_ appears in the current release, SCOPe 2.08